Species code:	VIBCH
Taxonomy:	Bacteria; Proteobacteria; Gammaproteobacteria; Vibrionales; Vibrionaceae; Vibrio (TaxID: 666) [NEWT/ NCBI]
Description:	Vibrio species represent a significant portion of the culturable heterotrophic bacteria of oceans, coastal waters and estuaries. Various species of this genus are devastating pathogens for finfish, shellfish and mammals. A Gram-negative, rod-shaped bacterium, V.cholerae is the etiological agent of cholera, a severe diarrheal disease that occurs most frequently in epidemic form. Cholera has been epidemic in southern Asia for at least 1000 years; epidemics are usually associated with poor sanitary conditions. Vibrio cholerae as a species includes both pathogenic and non pathogenic strains that vary in their virulence and gene content. There are 2 major serogroups that cause epidemic cholera, O1 and O139. Serogroup O1 is further classified into two biotypes, classical and El Tor, and into two major serotypes, Inaba and Ogawa. Analysis of epidemic O1 strains that caused cholera outbreaks in Latin America in 1991 revealed that the El Tor Inaba strains were unique to Latin America. O1 strains may exhibit serotype conversion or switching between Inaba and Ogawa serotypes.
Properties:	Presence of flagella: Yes Interaction: Animal pathogen in Mammalia Number of membranes: 2 Number of inteins:0
Statistics:	Number of VIBCH entries in the UniProt Knowledgebase: 3784 (907 in UniProtKB/Swiss-Prot + 2877 in UniProtKB/TrEMBL)

Genome structure:	• Chromosome 1 EMBL accession number AE003852 (circular; 2,961,149 bp) (download entry) (download Genome Reviews). • Chromosome 2 EMBL accession number AE003853 (circular; 1,072,315 bp) (download entry) (download Genome Reviews).
Reference(s):	[1] MEDLINE=20406833; PubMed=10952301; [ NCBI , EBI , Israel , Japan ] Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R., Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D., Vamathevan J.J., Bass S., Qin H., Dragoi I., Sellers P., McDonald L.A., Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L., Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M. ; "DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae."; Nature 406:477-483(2000).
Web links:	CBS: http://www.cbs.dtu.dk/services/GenomeAtlas/show-genus.php?kingdom=Bacteria&GLgenus=Vibrio&GLspecies=cholerae&GLstrain=N16961 CholeList: http://bioinfo.hku.hk/GenoList/index.pl?database=cholelist Entrez Genome Project: http://www.ncbi.nlm.nih.gov/sites/entrez?Db=genomeprj&Cmd=DetailsSearch&Term=txid243277%5Borgn%5D GIB (DDBJ): http://gib.genes.nig.ac.jp/single/index.php?spid=Vcho_N16961 Karyn's Genomes: http://www.ebi.ac.uk/2can/genomes/bacteria/Vibrio_cholerae.html NMPDR: http://www.nmpdr.org/FIG/seedviewer.cgi?pattern=243277.1;page=SearchResult PEDANT: http://pedant.gsf.de:3345/pedant3htmlview/pedant3view?Method=start_method&Db=p3_p36_Vib_chole TIGR CMR: http://cmr.tigr.org/tigr-scripts/CMR/GenomePage.cgi?database=gvc VchoCyc: http://biocyc.org/VCHO/organism-summary?object=VCHO  EBI Proteome Analysis page

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