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UniProtKB/Swiss-Prot entry A8ILC6

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name MDH_AZOC5
Primary accession number A8ILC6
Secondary accession numbers None
Integrated into Swiss-Prot on February 26, 2008
Sequence was last modified on December 4, 2007 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 10)
Name and origin of the protein
Protein name Malate dehydrogenase
Synonym EC 1.1.1.37
Gene name
Name: mdh
OrderedLocusNames: AZC_4016
From
Azorhizobium caulinodans (strain ATCC 43989 / DSM 5975 / ORS 571) [TaxID: 438753] [HAMAP proteome]
Taxonomy Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Xanthobacteraceae; Azorhizobium.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Lee K.B., Backer P.D., Aono T., Liu C.T., Suzuki S., Suzuki T., Kaneko T., Yamada M., Tabata S., Kupfer D.M., Najar F.Z., Wiley G.B., Roe B., Binnewies T., Ussery D., Vereecke D., Gevers D., Holsters M., Oyaizu H.;
"Complete genome sequence of the nitrogen-fixing bacterium Azorhizobium caulinodans ORS571.";
Submitted (APR-2007) to the EMBL/GenBank/DDBJ databases.
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AP009384; BAF90014.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq YP_001526932.1; -.
3D structure databases
ModBase A8ILC6.
Ontologies
GO
GO:0005488; Molecular function: binding (inferred from electronic annotation from InterPro).
GO:0030060; Molecular function: L-malate dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0006096; Biological process: glycolysis (inferred from electronic annotation from InterPro).
GO:0006108; Biological process: malate metabolic process (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0006099; Biological process: tricarboxylic acid cycle (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00487; -; 1.
PBIL [Tree]
InterPro IPR001557; L-lactate/malate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
IPR011275; Malate_DHase_NAD-dep_bac.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.90.110.10; lact_mal_DH; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000102; Lac_mal_DH; 1.
PRINTS PR00086; LLDHDRGNASE.
TIGRFAMs TIGR01763; MalateDH_bact; 1.
Genome annotation databases
GeneID 5687996; -.
GenomeReviews AP009384_GR; AZC_4016.
KEGG azc:AZC_4016; -.
CMR A8ILC6; AZC_4016.
Other
ProtoNet A8ILC6.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; NAD; Oxidoreductase; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   321  321     Malate dehydrogenase. PRO_1000072417
NP_BIND   10    15  6     NAD (By similarity). 
NP_BIND   119   121  3     NAD (By similarity). 
ACT_SITE   176   176        Proton acceptor (By similarity). 
BINDING   34    34        NAD (By similarity). 
BINDING   83    83        Substrate (By similarity). 
BINDING   89    89        Substrate (By similarity). 
BINDING   96    96        NAD (By similarity). 
BINDING   121   121        Substrate (By similarity). 
BINDING   152   152        Substrate (By similarity). 
Sequence information
Length: 321 AA [This is the length of the unprocessed precursor] Molecular weight: 33677 Da [This is the MW of the unprocessed precursor] CRC64: 2032149C7B46F9AE [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MARSKIALIG AGQIGGTLAL LAGLKELGDV VLFDLVEGVP QGKALDLAEL SPVAGFDAAF 

        70         80         90        100        110        120 
AGTGAYEQIA GADVVIVTAG VPRKPGMSRD DLLAVNLKVM EQAGAGIAKY APDAFVICVT 

       130        140        150        160        170        180 
NPLDAMVWAL QKASGLPRHK VVGMAGVLDS ARLRYFLADE FNVSVEDVTA MVLGGHGDTM 

       190        200        210        220        230        240 
VPLMRYCTVA GIPVPDLIRI GWTSTDRIEA IVTRTRNGGA EIVELLKSGS AFYAPAASAI 

       250        260        270        280        290        300 
VMAESYLKDK KRVLPVAAPL SGEYGFRDLY VGVPAVIGAR GVERIVELEL DRAERAQFEQ 

       310        320 
SVASVQGLVD ACAKIAPDLV R
A8ILC6 in FASTA format

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