ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!
Search for

UniProtKB/Swiss-Prot entry O67655

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

Note: most headings are clickable, even if they don't appear as links. They link to the user manual or other documents.
Entry information
Entry name MDH1_AQUAE
Primary accession number O67655
Secondary accession numbers None
Integrated into Swiss-Prot on June 1, 2001
Sequence was last modified on August 1, 1998 (Sequence version 1)
Annotations were last modified on    November 25, 2008 (Entry version 67)
Name and origin of the protein
Protein name Malate dehydrogenase 1
Synonym EC 1.1.1.37
Gene name
Name: mdh1
Synonyms: mdh
OrderedLocusNames: aq_1782
From
Aquifex aeolicus [TaxID: 63363] [HAMAP proteome]
Taxonomy Bacteria; Aquificae; Aquificales; Aquificaceae; Aquifex.
Protein existence 3: Inferred from homology;
References
[1]
 NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=VF5;
DOI=10.1038/32831; PubMed=9537320 [NCBI, ExPASy, EBI, Israel, Japan]
Deckert G., Warren P.V., Gaasterland T., Young W.G., Lenox A.L., Graham D.E., Overbeek R., Snead M.A., Keller M., Aujay M., Huber R., Feldman R.A., Short J.M., Olsen G.J., Swanson R.V.;
"The complete genome of the hyperthermophilic bacterium Aquifex aeolicus.";
Nature 392:353-358(1998).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
AE000657; AAC07619.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
PIR E70453; E70453.
RefSeq NP_214221.1; -.
3D structure databases
HSSP P80039; 1GV0. [HSSP ENTRY / PDB]
ModBase O67655.
Enzyme and pathway databases
BioCyc AAEO224324:AQ_1782-MON; -.
Ontologies
GO
GO:0005488; Molecular function: binding (inferred from electronic annotation from InterPro).
GO:0030060; Molecular function: L-malate dehydrogenase activity (inferred from electronic annotation from HAMAP).
GO:0006096; Biological process: glycolysis (inferred from electronic annotation from InterPro).
GO:0006108; Biological process: malate metabolic process (inferred from electronic annotation from InterPro).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
GO:0006099; Biological process: tricarboxylic acid cycle (inferred from electronic annotation from HAMAP).
QuickGo view.
Family and domain databases
HAMAP MF_00487; -; 1.
PBIL [Tree]
InterPro IPR001557; L-lactate/malate_DHase.
IPR001236; Lactate/malate_DHase.
IPR015955; Lactate_DHase/Glyco_Ohase_4_C.
IPR001252; Malate_DHase_AS.
IPR011275; Malate_DHase_NAD-dep_bac.
IPR016040; NAD(P)-bd.
Graphical view of domain structure.
Gene3D G3DSA:3.90.110.10; lact_mal_DH; 1.
G3DSA:3.40.50.720; NAD(P)-bd; 1.
Pfam PF02866; Ldh_1_C; 1.
PF00056; Ldh_1_N; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000102; Lac_mal_DH; 1.
PRINTS PR00086; LLDHDRGNASE.
TIGRFAMs TIGR01763; MalateDH_bact; 1.
Genome annotation databases
GeneID 1193462; -.
GenomeReviews AE000657_GR; aq_1782.
KEGG aae:aq_1782; -.
NMPDR fig|224324.1.peg.1236; -.
Phylogenomic databases
HOGENOM O67655; -.
Genome annotation databases
CMR O67655; aq_1782.
Other
ProtoNet O67655.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Complete proteome; NAD; Oxidoreductase; Tricarboxylic acid cycle.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
CHAIN   1   335  335     Malate dehydrogenase 1. PRO_0000113422
NP_BIND   11    16  6     NAD (By similarity). 
NP_BIND   133   135  3     NAD (By similarity). 
ACT_SITE   190   190        Proton acceptor (By similarity). 
BINDING   35    35        NAD (By similarity). 
BINDING   97    97        Substrate (By similarity). 
BINDING   103   103        Substrate (By similarity). 
BINDING   110   110        NAD (By similarity). 
BINDING   135   135        Substrate (By similarity). 
BINDING   166   166        Substrate (By similarity). 
Sequence information
Length: 335 AA [This is the length of the unprocessed precursor] Molecular weight: 36675 Da [This is the MW of the unprocessed precursor] CRC64: E02FA4C339237118 [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MRMKKTVAVI GAGNVGEHVA SLILLKNLAN VKMFDLPRKT EEKVFEPVKG KALDMKQMLA 

        70         80         90        100        110        120 
AMDIDARVEG YTVTPEGEGY EPLEGSDIVV ITAGFPRRPG MSREDLLEAN IRIISVIADR 

       130        140        150        160        170        180 
IKRYAPDAIV IVVTNPVDVM TYVAYKLLNF PKNRVMGMAG VLDSARFKTF ISEELMVSPK 

       190        200        210        220        230        240 
DIHAYVIGGH GDEMVPLISI SNVGGIPLKD LLPKEKLEKI IERTRFGGGE IVNLMGTSAY 

       250        260        270        280        290        300 
YAPAAAIVDM IEALVQNSKR ILPCSVYLDG EAGEYYGVQG FCVGVPVKLG SNGVEEIIKV 

       310        320        330 
PMIEEEREMW RRSVESVKKT VEVAEGILSA GSSRQ
O67655 in FASTA format

View entry in original UniProtKB/Swiss-Prot format
View entry in raw text format (no links)
Report form for errors/updates in this UniProtKB/Swiss-Prot entry

BLAST logo BLAST submission on ExPASy/SIB
or at NCBI (USA) 		Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
PROSITE logo ScanProsite, MotifScan SWISS-MODEL Submit a homology modeling request to SWISS-MODEL
NPSA logo NPSA Sequence analysis tools

ExPASy logo ExPASy Home page Site Map Search ExPASy Contact us Swiss-Prot
Hosted by au flag APAF Australia Mirror sites: Brazil Canada China Korea Switzerland
Notice: This page will be replaced with www.uniprot.org. Please send us your feedback!