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UniProtKB/Swiss-Prot entry P15279

[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DHM1_METOR
Primary accession number P15279
Secondary accession numbers None
Integrated into Swiss-Prot on April 1, 1990
Sequence was last modified on April 1, 1990 (Sequence version 1)
Annotations were last modified on    December 16, 2008 (Entry version 71)
Name and origin of the protein
Protein name Methanol dehydrogenase subunit 1 [Precursor]
Synonyms EC 1.1.99.8
MDH large alpha subunit
MEDH
Gene name
Name: moxF
From
Methylobacterium organophilum XX [TaxID: 410] 
Taxonomy Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales; Methylobacteriaceae; Methylobacterium.
Protein existence 1: Evidence at protein level;
References
[1]
 NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND PROTEIN SEQUENCE OF 28-43.
STRAIN=ATCC 27886 / DSM 760 / IFO 15689 / JCM 2833 / NCIB 11278;
PubMed=2459109 [NCBI, ExPASy, EBI, Israel, Japan]
Machlin S.M., Hanson R.S.;
"Nucleotide sequence and transcriptional start site of the Methylobacterium organophilum XX methanol dehydrogenase structural gene.";
J. Bacteriol. 170:4739-4747(1988).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
M22629; AAA50289.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
3D structure databases
HSSP P16027; 1H4J. [HSSP ENTRY / PDB]
SMR P15279; 28-622.
ModBase P15279.
Enzyme and pathway databases
BioCyc MetaCyc:MON-3927; -.
Ontologies
GO
GO:0030288; Cellular component: outer membrane-bounded periplasmic space (inferred from electronic annotation from InterPro).
GO:0005886; Cellular component: plasma membrane (inferred from electronic annotation from UniProtKB-KW).
GO:0018468; Molecular function: alcohol dehydrogenase (acceptor) activity (inferred from electronic annotation from EC).
GO:0005509; Molecular function: calcium ion binding (inferred from electronic annotation from UniProtKB-KW).
GO:0009055; Molecular function: electron carrier activity (inferred from electronic annotation from InterPro).
GO:0015945; Biological process: methanol metabolic process (inferred from electronic annotation from UniProtKB-KW).
GO:0055114; Biological process: oxidation reduction (inferred from electronic annotation from UniProtKB-KW).
QuickGo view.
Family and domain databases
InterPro IPR017512; PQQ_MeOH/EtOH_DH.
IPR002372; PQQ_repeat.
IPR011047; Quino_AlcDHase-like.
IPR001479; Quinoprotein_DHase_PQQ_bac_CS.
Graphical view of domain structure.
Gene3D G3DSA:2.140.10.10; Quinoprotein_alc_DH-like; 1.
Pfam PF01011; PQQ; 5.
Pfam graphical view of domain structure.
SMART SM00564; PQQ; 3.
SMART graphical view of domain structure.
PROSITE PS00363; BACTERIAL_PQQ_1; 1.
PS00364; BACTERIAL_PQQ_2; 1.
Other
ProtoNet P15279.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Calcium; Cell inner membrane; Cell membrane; Direct protein sequencing; Membrane; Metal-binding; Methanol utilization; Oxidoreductase; PQQ; Signal.
Features
SEVIEWER logo Feature table viewer
KeyFrom   To Length Description FTId
SIGNAL   1    27  27      
CHAIN   28   626  599     Methanol dehydrogenase subunit 1. PRO_0000025567
ACT_SITE   330   330        Proton acceptor (By similarity). 
METAL   204   204        Calcium (By similarity). 
METAL   288   288        Calcium (By similarity). 
DISULFID   130   131        By similarity. 
DISULFID   413   442        By similarity. 
Sequence information
Length: 626 AA [This is the length of the unprocessed precursor] Molecular weight: 68677 Da [This is the MW of the unprocessed precursor] CRC64: 8768F6B8371E5DFF [This is a checksum on the sequence] 
        10         20         30         40         50         60 
MSRFVTSVSA LAMLALAPAA LSSVAYANDK LVELSKSDDN WVMPGKNYDS NNYSELKQVN 

        70         80         90        100        110        120 
KSNVKQLRPA WTFSTGLLNG HEGAPLVVDG KMYVHTSFPN NTFALDLDDP GHILWQDKPK 

       130        140        150        160        170        180 
QNPAARAVAC CDLVNRGLAY WPGDGKTPAL ILKTQLDRHV VALNAETGET VWKVENSDIK 

       190        200        210        220        230        240 
VGSTLTIAPY VVKDKVIIGS SGAELGVRGY LTAYDVKTGG QVWRAYATGP DKDLLLADDF 

       250        260        270        280        290        300 
NVKNAHYGQK GLGTATWEGD AWKIGGGTNW GWYAYDPGTN LIYFGTGNPA PWNETMRPGD 

       310        320        330        340        350        360 
NKWTMTIFGR DADTGEAKFG YQKTPHDEWD YAGVNVMMPS EQKDKDGKTR KLLTHPDRNG 

       370        380        390        400        410        420 
IVYTLDRTDG ALVSANKLDD TVNVFKTVDL KTGQPVRDPE YGTRMDHLAK DVCPSAMGYH 

       430        440        450        460        470        480 
NQGHDSYDPK RELFFMGINH ICMDWEPFML PYRAGQFFVG ATLNMYPGPK GDRQNYEGLG 

       490        500        510        520        530        540 
QIKAYNAITG SYKWEKMERF AVWGGTLATA GDLVFYGTLD GYLKARDSDT GDLLWKFKIP 

       550        560        570        580        590        600 
SGAIGYPMTY THKGTQYVAI YYGVGGWPGV GLVFDLADPT AGLGAVGAFK KLANYTQQGG 

       610        620 
GVIVFSLDGK GPYDDPNVGE WKSASK
P15279 in FASTA format

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