ID   DHOM_METGL              Reviewed;         435 AA.
AC   P37143;
DT   01-OCT-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1994, sequence version 1.
DT   04-NOV-2008, entry version 41.
DE   RecName: Full=Homoserine dehydrogenase;
DE            Short=HDH;
DE            EC=1.1.1.3;
GN   Name=hom;
OS   Methylobacillus glycogenes.
OC   Bacteria; Proteobacteria; Betaproteobacteria; Methylophilales;
OC   Methylophilaceae; Methylobacillus.
OX   NCBI_TaxID=406;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 21276;
RX   MEDLINE=94161493; PubMed=8117070;
RA   Motoyama H., Maki K., Anazawa H., Ishino S., Teshiba S.;
RT   "Cloning and nucleotide sequences of the homoserine dehydrogenase
RT   genes (hom) and the threonine synthase genes (thrC) of the Gram-
RT   negative obligate methylotroph Methylobacillus glycogenes.";
RL   Appl. Environ. Microbiol. 60:111-119(1994).
CC   -!- CATALYTIC ACTIVITY: L-homoserine + NAD(P)(+) = L-aspartate 4-
CC       semialdehyde + NAD(P)H.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-methionine biosynthesis via de
CC       novo pathway; L-homoserine from L-aspartate: step 3/3.
CC   -!- PATHWAY: Amino-acid biosynthesis; L-threonine biosynthesis; L-
CC       threonine from L-aspartate: step 3/5.
CC   -!- SIMILARITY: Belongs to the homoserine dehydrogenase family.
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DR   EMBL; D14070; BAA40414.1; -; Genomic_DNA.
DR   GO; GO:0009097; P:isoleucine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009086; P:methionine biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0009088; P:threonine biosynthetic process; IEA:UniProtKB-KW.
DR   InterPro; IPR005106; Asp/hSer_DHase_NAD-bd.
DR   InterPro; IPR001342; hSer_DHase_cat.
DR   Pfam; PF00742; Homoserine_dh; 1.
DR   Pfam; PF03447; NAD_binding_3; 1.
DR   PROSITE; PS01042; HOMOSER_DHGENASE; FALSE_NEG.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis; Branched-chain amino acid biosynthesis;
KW   Isoleucine biosynthesis; Methionine biosynthesis; NADP;
KW   Oxidoreductase; Threonine biosynthesis.
FT   CHAIN         1    435       Homoserine dehydrogenase.
FT                                /FTId=PRO_0000066698.
FT   NP_BIND       9     16       NADP (By similarity).
FT   ACT_SITE    204    204       Proton donor (Potential).
FT   BINDING     105    105       NADP (By similarity).
FT   BINDING     190    190       Substrate (By similarity).
SQ   SEQUENCE   435 AA;  48227 MW;  58468B0E7A81ACAB CRC64;
     MKPINVGLLG IGTVGGGTYT VLTRNQEGNR APCRPPNCHH ARRDRNLELA RKVTGGQIDV
     TDDAFAVVVR PRHRHRGRID RRIHHRARTG YEGDRERQAR VAANKALMLA WQRDFRRVAQ
     QKGVIVAFEA AVAGGIPIIK AVAAGAGRQP SSRVLRAIIN GTTNFILSEM REKGLAFADV
     LKEAQPRLCE ATRPSTSRAW TAHKLMILAA IGFGIPMQFD KAYVEGISKL DALDIRYAEE
     LGYRQAAWHA PSAPARGVEL ARAPDPDPRE TPDRQCQRRH NAVLVSDACR SHLVYRPDAC
     RRHASAVVAD IVDGTRTAYH RRAPAVPHLL SSPTSSWTCR FAIGEVSSAY YLRLRAVDKP
     GRDGHVTRIL ATGSLHRCDD SEGNRRQAER RRSGRHHHPD HVTVEKNMDD AIVAIEALPA
     ISGSVTRLRM EELSR
//