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UniProtKB/Swiss-Prot entry P63630


[Entry info] [Name and origin] [References] [Comments] [Cross-references] [Keywords] [Features] [Sequence] [Tools]

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Entry information
Entry name DHOM_MYCBO
Primary accession number P63630
Secondary accession number Q10601
Integrated into Swiss-Prot on October 11, 2004
Sequence was last modified on October 11, 2004 (Sequence version 1)
Annotations were last modified on    July 22, 2008 (Entry version 23)
Name and origin of the protein
Protein name Homoserine dehydrogenase
Synonyms HDH
EC 1.1.1.3
Gene name
Name: hom
Synonyms: thrA
OrderedLocusNames: Mb1326
From
Mycobacterium bovis [TaxID: 1765] [HAMAP proteome]
Taxonomy Bacteria; Actinobacteria; Actinobacteridae; Actinomycetales; Corynebacterineae; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex.
Protein existence 3: Inferred from homology;
References
[1]
NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
STRAIN=ATCC BAA-935 / AF2122/97;
DOI=10.1073/pnas.1130426100; PubMed=12788972 [NCBI, ExPASy, EBI, Israel, Japan]
Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M., Duthoy S., Grondin S., Lacroix C., Monsempe C., Simon S., Harris B., Atkin R., Doggett J., Mayes R., Keating L., Wheeler P.R., Parkhill J., Barrell B.G., Cole S.T., Gordon S.V., Hewinson R.G.;
"The complete genome sequence of Mycobacterium bovis.";
Proc. Natl. Acad. Sci. U.S.A. 100:7877-7882(2003).
Comments
Copyright
Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms. Distributed under the Creative Commons Attribution-NoDerivs License.
Cross-references
Sequence databases
EMBL
BX248338; CAD94187.1; -; Genomic_DNA.[EMBL / GenBank / DDBJ] [CoDingSequence]
RefSeq NP_854980.1; -.
3D structure databases
ModBase P63630.
Family and domain databases
InterPro IPR002912; ACT_bd.
IPR005106; Asp/hSer_DHase_NAD-bd.
IPR016204; hSer_DHase.
IPR001342; hSer_DHase_cat.
Graphical view of domain structure.
Pfam PF01842; ACT; 1.
PF00742; Homoserine_dh; 1.
PF03447; NAD_binding_3; 1.
Pfam graphical view of domain structure.
PIRSF PIRSF000098; Homoser_dehydrog; 1.
PROSITE PS01042; HOMOSER_DHGENASE; 1.
BLOCKS P63630.
Genome annotation databases
GeneID 1090613; -.
GenomeReviews BX248333_GR; Mb1326.
KEGG mbo:Mb1326; -.
Phylogenomic databases
HOGENOM P63630; -.
Genome annotation databases
CMR P63630; Mb1326.
Other
ProtoNet P63630.
UniRef View cluster of proteins with at least 50% / 90% / 100% identity.
Keywords
Amino-acid biosynthesis; Branched-chain amino acid biosynthesis; Complete proteome; Isoleucine biosynthesis; Methionine biosynthesis; NADP; Oxidoreductase; Threonine biosynthesis.
Features
SEVIEWER logo Feature table viewer FT aligner logo Feature aligner
KeyFrom   To Length Description FTId
CHAIN   1   441  441     Homoserine dehydrogenase. PRO_0000066700
DOMAIN   355   433  79     ACT. 
NP_BIND   13    20  8     NADP (By similarity). 
ACT_SITE   207   207        Proton donor (Potential). 
BINDING   107   107        NADP (By similarity). 
BINDING   192   192        Substrate (By similarity). 
Sequence information
Length: 441 AA [This is the length of the unprocessed precursor] Molecular weight: 45553 Da [This is the MW of the unprocessed precursor] CRC64: 818248C137885BE8 [This is a checksum on the sequence]
        10         20         30         40         50         60 
MPGDEKPVGV AVLGLGNVGS EVVRIIENSA EDLAARVGAP LVLRGIGVRR VTTDRGVPIE 

        70         80         90        100        110        120 
LLTDDIEELV AREDVDIVVE VMGPVEPSRK AILGALERGK SVVTANKALL ATSTGELAQA 

       130        140        150        160        170        180 
AESAHVDLYF EAAVAGAIPV IRPLTQSLAG DTVLRVAGIV NGTTNYILSA MDSTGADYAS 

       190        200        210        220        230        240 
ALADASALGY AEADPTADVE GYDAAAKAAI LASIAFHTRV TADDVYREGI TKVTPADFGS 

       250        260        270        280        290        300 
AHALGCTIKL LSICERITTD EGSQRVSARV YPALVPLSHP LAAVNGAFNA VVVEAEAAGR 

       310        320        330        340        350        360 
LMFYGQGAGG APTASAVTGD LVMAARNRVL GSRGPRESKY AQLPVAPMGF IETRYYVSMN 

       370        380        390        400        410        420 
VADKPGVLSA VAAEFAKREV SIAEVRQEGV VDEGGRRVGA RIVVVTHLAT DAALSETVDA 

       430        440 
LDDLDVVQGV SSVIRLEGTG L 

P63630 in FASTA format

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BLAST logo BLAST submission on ExPASy/SIB
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Tools Sequence analysis tools: ProtParam, ProtScale, Compute pI/Mw, PeptideMass, PeptideCutter, Dotlet (Java)
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NPSA logo NPSA Sequence analysis tools

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